Changing memories on the fly: the neural circuits of memory re-evaluation in Drosophila melanogaster

Associative learning leads to modifications in neural networks to assign valence to sensory cues. These changes not only allow the expression of learned behavior but also modulate subsequent learning events. In the brain of the adult fruit fly, Drosophila melanogaster, olfactory memories are established as dopamine-driven plasticity in the output of a highly recurrent network, the mushroom body. Recent findings have highlighted how these changes in the network can steer the strengthening, weakening and formation of parallel memories when flies are exposed to subsequent training trials, conflicting situations or the reversal of contingencies. Together, these processes provide an initial understanding of how learned information can be used to guide the re-evaluation of memories.