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Related Experiment Video

Updated: Nov 23, 2025

Breath Collection from Children for Disease Biomarker Discovery
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Exhaled breath analysis in disease detection.

Ting Chen1, Tiannan Liu1, Ting Li1

  • 1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, PR China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|January 2, 2021
PubMed
Summary

Exhaled breath analysis offers a promising, non-invasive method for diagnosing and monitoring various diseases. This review explores current and emerging technologies for breath analysis, highlighting its potential for early disease detection.

Keywords:
Disease diagnosisExhaled breathVolatile organic compounds

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Pulmonology

Background:

  • Exhaled breath analysis is gaining traction for disease diagnosis.
  • Traditional diagnostic methods can be invasive and costly.
  • Breath analysis offers a non-invasive alternative for disease detection.

Purpose of the Study:

  • To review conventional and emerging technologies for exhaled breath analysis.
  • To explore the application of breath analysis in diagnosing lung, gastrointestinal, metabolic, and kidney diseases.
  • To correlate breath components with specific disease markers.

Main Methods:

  • Literature review of existing research on exhaled breath analysis.
  • Discussion of various analytical techniques and devices for breath sampling and analysis.
  • Correlation of identified breath biomarkers with specific disease conditions.

Main Results:

  • Exhaled breath contains volatile organic compounds (VOCs) indicative of various diseases.
  • Specific VOC profiles are associated with lung diseases, inflammation, and metabolic disorders.
  • Emerging technologies show potential for improved sensitivity and specificity in breath analysis.

Conclusions:

  • Exhaled breath analysis is a viable, non-invasive tool for disease diagnosis and monitoring.
  • Further research and technological advancements can enhance its clinical application.
  • Breath analysis represents a new frontier in early disease detection and screening.