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Updated: Nov 23, 2025

Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies
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Published on: July 3, 2025

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The Role of CDK5 in Tumours and Tumour Microenvironments

Phuong Anh Do1, Chang Hoon Lee1

  • 1Phamaceutical Biochemistry, College of Pharmacy, BK21 FOUR Team, and Integrated Research Institute for Drug Development, Dongguk University, Goyang 100-715, Korea.

Cancers
|January 5, 2021
PubMed

Insights

Cyclin-dependent kinase 5 (CDK5) regulates neurons but drives cancer progression. This review explores CDK5

Area of Science:

  • Molecular Biology
  • Oncology
  • Neuroscience

Background:

  • Cyclin-dependent kinase 5 (CDK5) is a key regulator of neuronal function.
  • Aberrant CDK5 activity is implicated in the development and progression of various cancers.
  • CDK5 influences critical cancer hallmarks including proliferation, apoptosis, and angiogenesis.

Purpose of the Study:

  • To review the dual role of CDK5 in neuronal function and cancer.
  • To summarize current knowledge on CDK5 inhibitors for cancer therapy.
  • To provide insights for developing novel CDK5-targeted cancer treatments.

Main Methods:

  • Literature review of studies on CDK5 in cancer and neuroscience.
  • Analysis of CDK5's involvement in cell proliferation, apoptosis, angiogenesis, inflammation, and immune response.
  • Compilation of information on existing and potential CDK5 inhibitors.

Main Results:

  • CDK5 plays a crucial role in normal neuronal function.
  • Dysregulated CDK5 activity promotes tumor progression across multiple cancer types.
  • CDK5 inhibitors show promise as a therapeutic strategy for refractory cancers.

Conclusions:

  • CDK5 is a significant target for cancer therapy due to its role in tumor progression.
  • Further research into CDK5 inhibitors could lead to effective treatments for difficult-to-treat cancers.
  • Understanding CDK5's mechanisms in both neurons and cancer is vital for therapeutic development.
Keywords:
CDK5cancermicrotubuleneurontumour microenvironments

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