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Preparation of Nanoparticles for ToF-SIMS and XPS Analysis
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Safe Nanoparticles: Are We There Yet?
Wided Najahi-Missaoui1, Robert D Arnold2,3, Brian S Cummings1,3
1Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA 30602, USA.
International Journal of Molecular Sciences
|January 5, 2021
Summary
Nanoparticle applications are expanding, but safety questions remain. This review covers nanoparticle toxicity, cell interactions, and methods to ensure safer nanotechnology development.
Area of Science:
- Nanotechnology and Nanomedicine
- Materials Science
- Toxicology
Background:
- Nanotechnology has advanced significantly, moving from research labs to practical applications.
- Nanoparticles offer diverse uses in drug delivery, diagnostics, and cosmetics.
- Growing applications raise critical questions regarding nanoparticle safety.
Purpose of the Study:
- To review the current understanding of nanoparticle toxicity.
- To examine nanoparticle interactions with biological systems, particularly mammalian cells.
- To summarize strategies for minimizing nanoparticle-induced toxicity.
Main Methods:
- Literature review of peer-reviewed studies on nanoparticle safety and toxicity.
- Analysis of research on nanoparticle interactions with cellular mechanisms.
- Compilation of data on risk assessment and mitigation strategies.
Main Results:
- Nanoparticles exhibit broad applicability but also potential toxic effects.
- Understanding nanoparticle-cell interactions is crucial for safety assessment.
- Several approaches exist to mitigate nanoparticle toxicity.
Conclusions:
- Continued research is necessary to fully address nanoparticle safety concerns.
- Implementing safety strategies is vital for the responsible advancement of nanotechnology.
- This review provides a foundation for developing safer nanomaterials and applications.
