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Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging
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Imaging Sequences for Hyperpolarized Solids.

Xudong Lv1, Jeffrey Walton2, Emanuel Druga1

  • 1Department of Chemistry, University of California, Berkeley, CA 94720, USA.

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|January 5, 2021
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Summary
This summary is machine-generated.

This study presents a theoretical framework for imaging hyperpolarized solids using Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI). It addresses challenges in maintaining polarization for optimal image quality in solids.

Keywords:
flip anglehyperpolarizationmagnetic resonance imaging

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Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Nuclear Magnetic Resonance (NMR)
  • Solid-state Physics

Background:

  • Hyperpolarization enhances NMR and MRI signals by increasing nuclear spin state population differences.
  • Imaging hyperpolarized solids is challenging due to non-replenishable polarization and short decoherence times.

Purpose of the Study:

  • To develop a theoretical framework for optimizing image quality in hyperpolarized solids.
  • To address the challenge of polarization budgeting in MRI sequences for solids.

Main Methods:

  • Theoretical framework developed for variable and constant flip angle MRI sequences.
  • Analysis of gradient arrangements for fast imaging of solids.
  • Demonstration using hyperpolarized diamonds as a test platform.

Main Results:

  • A theoretical framework is presented for managing polarization in hyperpolarized solids.
  • Fast imaging strategies are analyzed to overcome decoherence.
  • Hyperpolarized diamond imaging serves as a validation case.

Conclusions:

  • The developed framework provides a method for optimizing hyperpolarized solids imaging.
  • Fast imaging techniques are crucial for MRI of solids with short decoherence times.
  • Hyperpolarized diamonds are a viable platform for testing these advanced MRI techniques.