Related Experiment Video
Updated: Nov 23, 2025
10:22
Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
Published on: December 4, 2015
9.1K
Congenital malaria by Plasmodium falciparum
José Gabriel Del Castillo Calderón1, Angie Milena Cárdenas Silva2
1Hospital Infantil Los Ángeles, Colombia.
Revista Chilena De Pediatria
|January 5, 2021
Summary
Congenital malaria (CM) in newborns presents with non-specific symptoms mimicking sepsis. Early diagnosis and treatment of Plasmodium falciparum congenital malaria are crucial to prevent severe neonatal disease.
Area of Science:
- Tropical medicine
- Neonatology
- Infectious diseases
Background:
- Congenital malaria (CM) is a Plasmodium infection acquired in utero or during delivery.
- Plasmodium falciparum poses a severe risk to pregnant women and newborns.
Observation:
- Two cases of CM caused by Plasmodium falciparum in neonates presented with sepsis-like symptoms.
- Initial antibiotic treatment for presumed sepsis was ineffective.
- Peripheral blood smear confirmed Plasmodium falciparum infection after one week of life.
Findings:
- Intravenous quinine treatment led to clinical improvement in both neonates.
- Mothers had a history of malaria during pregnancy, with one experiencing severe malaria at delivery.
Implications:
- CM should be considered in the differential diagnosis of neonatal sepsis, especially in infants born to mothers with malaria exposure.
- Prompt diagnosis and treatment of congenital malaria reduce the risk of severe neonatal complications.
More Related Videos
Related Concept Videos
00:58Symbiosis
35.9K
Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
35.9K
01:27Diversity of Protists II
611
Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
611
01:20Inborn Errors of Metabolism
530
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
530