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Test-retest repeatability of quantitative bone SPECT/CT.

Tomohiko Yamane1, Kenji Fukushima2, Suguru Shirotake3

  • 1Department of Nuclear Medicine, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, 350-1298, Japan. yamane_t@saitama-med.ac.jp.

Annals of Nuclear Medicine
|January 5, 2021
PubMed
Summary

The standardized uptake value (SUV) in bone SPECT/CT shows high test-retest repeatability, with almost perfect correlation for SUVmax and SUVpeak. These quantitative values are reliable for patient management in prostate cancer bone imaging.

Keywords:
Bone metastasisQuantitative SPECT/CTRepeatabilityStandardized uptake value (SUV)[99mtc] Methylene diphosphonate (99mtc-MDP)

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Area of Science:

  • Nuclear Medicine
  • Radiology
  • Oncology

Background:

  • Technological advancements in SPECT imaging allow for quantitative uptake evaluation using standardized uptake values (SUV).
  • The reliability of SUV measurements in bone SPECT/CT, particularly for prostate cancer, requires robust validation.
  • Establishing SUV repeatability is crucial for its clinical application in semi-quantitative analysis.

Purpose of the Study:

  • To evaluate the test-retest repeatability of standardized uptake values (SUV) in bone SPECT/CT.
  • To assess the reliability of SUVmax and SUVpeak measurements in various bone lesion types.

Main Methods:

  • Prospective study of prostate cancer patients undergoing bone SPECT/CT.
  • Dual acquisition of bone SPECT/CT images within a 4-10 day interval.
  • Calculation of SUVmax and SUVpeak for normal bone, degeneration/fracture, and metastatic lesions using statistical indicators (ICC, RC, MAPD).

Main Results:

  • High intraclass correlation coefficients (ICCs) observed: 0.968 for SUVmax and 0.976 for SUVpeak.
  • Repeatability coefficients (RCs) were 30.7% for SUVmax and 27.6% for SUVpeak.
  • Mean absolute percentage differences (MAPDs) were 12.3% for SUVmax and 11.5% for SUVpeak, comparable to PET studies.

Conclusions:

  • Bone SPECT/CT demonstrates almost perfect correlation for repeated SUVmax and SUVpeak measurements.
  • Quantitative SUV values derived from bone SPECT/CT are reliable indicators for clinical use.
  • These findings support the use of quantitative SPECT/CT in prostate cancer patient management.