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Association between diabetes and haematological malignancies: a population-based study.
Inna Y Gong1, Matthew C Cheung1,2,3, Stephanie Read4
1Department of Medicine, University of Toronto, Toronto, ON, Canada.
Diabetologia
|January 7, 2021
Summary
Individuals with diabetes face a higher risk of developing blood cancers (hematological malignancies) and increased mortality. Lifestyle changes may help reduce both diabetes and cancer risks.
Area of Science:
- Hematology
- Oncology
- Epidemiology
Background:
- Contemporary data on the association between diabetes and hematological malignancies are limited.
- Understanding this link is crucial for public health and clinical practice.
Purpose of the Study:
- To evaluate the risk of developing hematological malignancies in individuals with diabetes.
- To assess the subsequent mortality associated with diabetes in these patients.
Main Methods:
- A population-based observational study using Canadian healthcare databases (1996-2015).
- Included over 1 million individuals with diabetes and over 2 million matched controls without diabetes.
- Utilized Cox regression to analyze the association between diabetes and hematological malignancy risk and mortality.
Main Results:
- Individuals with diabetes had a significantly higher risk of hematological malignancies (adjusted HR 1.10).
- This increased risk was observed across all time periods post-diabetes diagnosis.
- Diabetes was associated with higher all-cause and cause-specific mortality among those diagnosed with hematological malignancies.
Conclusions:
- Diabetes is an independent risk factor for developing hematological malignancies.
- Diabetes is also an independent risk factor for increased mortality in patients with hematological malignancies.
- Lifestyle modifications may reduce diabetes burden and potentially lower malignancy risk and mortality.
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