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Related Experiment Videos

Candida. A decreasing problem for the burned patient?

B J Grube1, J A Marvin, D M Heimbach

  • 1Department of Surgery, University of Washington, Seattle.

Archives of Surgery (Chicago, Ill. : 1960)
|February 1, 1988
PubMed
Summary
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Candida wound infections and sepsis are potential complications in severe burn injuries. However, this study found Candida septicemia was not a major cause of mortality in burn patients under current management.

Area of Science:

  • Infectious Diseases
  • Burn Care
  • Critical Care Medicine

Background:

  • Candida wound infections and sepsis are reported as significant complications in severe burn injuries.
  • Current burn treatment protocols involve aggressive excision, grafting, and specific antifungal/antibiotic strategies.

Purpose of the Study:

  • To evaluate the incidence and impact of Candida infections, particularly sepsis, in severely burned patients.
  • To assess the effectiveness of the current management regimen in preventing Candida-related morbidity and mortality.

Main Methods:

  • Retrospective review of 168 severely burned patients admitted to a burn intensive care unit over 18 months.
  • Analysis of Candida culture positivity from various sites and blood cultures.
  • Diagnosis of Candida sepsis based on clinical signs, positive blood cultures, and additional positive cultures.

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Main Results:

  • Thirteen percent of patients had at least one positive Candida culture.
  • Three patients (1.8%) developed Candida sepsis, with one fatality (0.6% overall mortality).
  • All sepsis cases were treated with amphotericin B.

Conclusions:

  • Under the reviewed management regimen, Candida septicemia was not a primary driver of morbidity or mortality in this cohort of severely burned patients.
  • The current treatment strategies appear effective in controlling severe Candida infections in burn intensive care unit settings.