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Related Concept Videos

Mitosis and Cytokinesis01:35

Mitosis and Cytokinesis

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In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
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Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

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In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
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Nucleosome Remodeling02:54

Nucleosome Remodeling

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Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
Nucleosome remodeling complex
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Disassembly of Intermediate Filaments01:35

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Intermediate filaments (IFs) do not undergo spontaneous disassembly. Enzymes, kinases, and phosphatases add and remove phosphates from specific sites to regulate their disassembly. The IF concentration in the cytoplasm also regulates the disassembly. If the concentration crosses a threshold, it activates the protein kinases in the vicinity, allowing the phosphorylation of IFs.
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Meiosis II01:57

Meiosis II

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Meiosis II is the second and final stage of meiosis. It relies on the haploid cells produced during meiosis I, each of which contain only 23 chromosomes—one from each homologous initial pair. Importantly, each chromosome in these cells is composed of two joined copies, and when these cells enter meiosis II, the goal is to separate such sister chromatids using the same microtubule-based network employed in other division processes. The result of meiosis II is two haploid cells, each...
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Meiosis II02:02

Meiosis II

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Meiosis II entails cell division and segregation of the sister chromatids, resulting in the production of four unique haploid gametes. The steps for meiosis II are similar to mitosis, except that meiosis II occurs in haploid cells, whereas mitosis occurs in diploid cells.
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Updated: Nov 22, 2025

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy
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Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy

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Nuclear envelope remodelling during mitosis.

Gautam Dey1, Buzz Baum2

  • 1Cell Biology and Biophysics, European Molecular Biology Laboratory, 69117, Heidelberg, Germany.

Current Opinion in Cell Biology
|January 9, 2021
PubMed
Summary
This summary is machine-generated.

Eukaryotic cells manage nuclear envelope dynamics during cell division through diverse strategies, either disassembling and reassembling the nucleus or maintaining its integrity. This review explores the mechanisms, challenges, and evolutionary pressures behind these distinct nuclear division modes.

Keywords:
EukaryogenesisLaminaMitosisNuclear divisionNuclear envelopeNuclear pore complex

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Area of Science:

  • Cell Biology
  • Genetics
  • Evolutionary Biology

Background:

  • The eukaryotic nucleus, enclosed by a double envelope, separates the genome from the cytoplasm.
  • Nuclear pores regulate transport, but the envelope poses challenges during cell division (mitosis).

Purpose of the Study:

  • To review mechanisms of nuclear envelope remodeling during eukaryotic cell division.
  • To discuss topological challenges and evolutionary pressures driving distinct division strategies.

Main Methods:

  • Literature review of eukaryotic cell division processes.
  • Analysis of nuclear envelope dynamics during mitosis.
  • Comparative study of different eukaryotic division modes.

Main Results:

  • Eukaryotes employ diverse strategies for nuclear division, ranging from complete disassembly to intact maintenance of the nuclear envelope.
  • Common features in division processes underpin nuclear envelope remodeling mechanisms.
  • Topological challenges are inherent in maintaining or reforming the nuclear boundary.

Conclusions:

  • Evolution has favored distinct nuclear division strategies in eukaryotes.
  • Understanding these strategies provides insight into fundamental cell biology and evolution.
  • Selective pressures likely drive the diversity of nuclear division mechanisms.