Transcriptional Circuits Regulating Developmental Processes in Candida albicans
Diana L Rodriguez1,2, Morgan M Quail1,2, Aaron D Hernday1,3
1Department of Molecular and Cell Biology, School of Natural Sciences, University of California-Merced, Merced, CA, United States.
Frontiers in Cellular and Infection Microbiology
|January 11, 2021
Summary
Candida albicans, a common fungus, can be both a harmless microbe and a dangerous pathogen. Understanding its transcriptional regulation is key to controlling infections.
Area of Science:
- Microbiology
- Mycology
- Molecular Biology
Background:
- * *Candida albicans* is a human commensal and opportunistic pathogen.
- * It colonizes various body sites and causes infections, particularly in immunocompromised individuals.
- * Adaptation requires sophisticated transcriptional regulation in response to host signals.
Purpose of the Study:
- * To identify and characterize transcriptional regulatory networks in *C. albicans*.
- * To understand how these networks control key developmental processes.
- * To elucidate strategies for *C. albicans* colonization and infection.
Main Methods:
- * Analysis of transcriptional regulatory circuits.
- * Examination of biofilm formation, white-opaque switch, and commensal-pathogen transition.
- * Investigation of regulatory crosstalk between core regulators.
Main Results:
- * Three major developmental processes are controlled by distinct transcriptional circuits.
- * These circuits are interconnected through extensive regulatory crosstalk.
- * Core regulators integrate signals for developmental processes.
Conclusions:
- * Transcriptional regulatory networks are crucial for *C. albicans* adaptation.
- * Interconnected circuits enable the fungus to switch between commensal and pathogenic states.
- * Understanding these networks offers insights into fungal pathogenesis and control.
Keywords:
Candida albicansbiofilmscommensal-pathogen transitiontranscriptional circuitstranscriptional networkstranscriptional regulationtranscriptional rewiringwhite-opaque switchingMore Related Videos
07:48Genome-wide Profiling of Transcription Factor-DNA Binding Interactions in Candida albicans: A Comprehensive CUT&RUN Method and Data Analysis Workflow
Published on: April 1, 2022
4.4K
11:14Visualization of Biofilm Formation in Candida albicans Using an Automated Microfluidic Device
Published on: December 14, 2017
10.9K
Related Concept Videos
01:28Yeast Signaling
16.6K
Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
16.6K
01:17Gene Regulation During Sporulation
253
Sporulation is a complex developmental process that allows certain Gram-positive bacteria, such as Bacillus subtilis and Clostridium species, to survive extreme environmental conditions. This process is tightly regulated by a series of signaling cascades and transcriptional controls, ensuring the formation of a highly resistant endospore.Sporulation is triggered by unfavorable conditions, such as nutrient depletion, and is governed by a phosphorelay system. One of the sensor kinases, such as...
253
02:19Circadian Rhythms and Gene Regulation
4.3K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.3K
01:58Prokaryotic Transcriptional Activators and Repressors
24.4K
The organization of prokaryotic genes in their genome is notably different from that of eukaryotes. Prokaryotic genes are organized, such that the genes for proteins involved in the same biochemical process or function are located together in groups. This group of genes, along with their regulatory elements, are collectively known as an operon. The functional genes in an operon are transcribed together to give a single strand of mRNA known as polycistronic mRNA.
Transcription of prokaryotic...
Transcription of prokaryotic...
24.4K
01:58Prokaryotic Transcriptional Activators and Repressors
9.9K
9.9K
02:02Cis-regulatory Sequences
11.2K
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
11.2K