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3D bioprinting dermal-like structures using species-specific ulvan.

Xifang Chen1, Zhilian Yue, Pia C Winberg

  • 1ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, Innovation Campus, University of Wollongong, NSW 2500, Australia. zyue@uow.edu.au gwallace@uow.edu.au.

Biomaterials Science
|January 11, 2021
PubMed
Summary

Researchers developed a novel bioink for skin tissue engineering by combining gelatin methacryloyl (GelMA) with ulvan polysaccharide. This enhanced bioink improves 3D printing, mechanical strength, and cell viability for skin repair applications.

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • 3D bioprinting is crucial for skin tissue engineering, but bioink tunability remains a challenge.
  • Existing bioinks often lack specific biocompatibility, functional traits, and optimal printability.
  • Gelatin methacryloyl (GelMA) is a common bioink base, but requires modification for enhanced performance.

Purpose of the Study:

  • To develop a tunable and biofunctional bioink for skin tissue engineering.
  • To enhance the properties of gelatin methacryloyl (GelMA) bioinks using ulvan polysaccharide.
  • To evaluate the printability, mechanical properties, and biological performance of the novel bioink.

Main Methods:

  • A novel bioink was formulated by combining GelMA with methacrylated ulvan (UlMA) derived from Australian macroalgae (Ul84).

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  • The bioink's printability, mechanical strength, and degradation rates were assessed.
  • 3D bioprinted constructs laden with human dermal fibroblasts were evaluated for cell viability, proliferation, and extracellular matrix deposition.

    • Main Results:

    • UlMA addition improved GelMA bioink printability by reducing yield stress.
    • The ulvan-containing bioinks exhibited enhanced mechanical strength and controlled degradation rates.
    • 3D bioprinted skin constructs showed high cell viability, proliferation, and deposition of collagen I, collagen III, elastin, and fibronectin.

    Conclusions:

    • The developed GelMA-UlMA bioink offers improved printability, mechanical stability, and biofunctionality for skin tissue engineering.
    • Ulvan polysaccharide incorporation enhances scaffold structural integrity and supports dermal-like tissue formation.
    • This novel bioink shows significant potential for advancing skin tissue repair and regenerative medicine applications.