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Updated: Nov 22, 2025

Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
Continuous Engagement in a Weight-Loss Program Promotes Sustained Significant Weight Loss
Nia S Mitchell1, Emmanuel A Seyoum2, Nrupen A Bhavsar3
1Division of General Internal Medicine, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, nia.s.mitchell@duke.edu.
Long-term engagement in the Take Off Pounds Sensibly (TOPS) weight-loss program led to significant weight loss in over 60% of members by year seven. Continuous participation is encouraged for sustained health improvements.
Area of Science:
- Obesity and Weight Management
- Public Health Interventions
- Behavioral Science
Background:
- Significant weight loss is crucial for improving health outcomes.
- Weight regain remains a common challenge following initial weight loss efforts.
- Peer-led, low-cost programs offer accessible weight management solutions.
Purpose of the Study:
- To evaluate the long-term effectiveness of the Take Off Pounds Sensibly (TOPS) program.
- To determine if members achieved and maintained significant weight loss over seven consecutive years.
- To analyze weight change patterns within a large, national weight-loss program.
Main Methods:
- Retrospective cohort study design.
- Analysis of 2,346 members with 7 consecutive annual renewals.
- Categorization of weight change: significant loss (≥5%), weight stable (0-5% loss), and weight gain.
Main Results:
- 51% of participants maintained significant weight loss throughout the 7-year study period.
- 18% achieved significant weight loss initially but transitioned to other categories later.
- 25% remained in the weight-stable category, and 7% experienced weight gain by year 7.
Conclusions:
- Over 60% of TOPS members achieved significant weight loss by year 7.
- Continuous, long-term engagement in weight-loss programs promotes sustained results.
- Encouraging participation is vital, even for individuals not achieving immediate significant weight loss.
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