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Synthetic Biology

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Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
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Microorganisms play a pivotal role in maintaining ecosystem balance by recycling essential elements such as carbon, nitrogen, and phosphorus, as well as supporting processes like bioremediation, wastewater treatment, and biofuel production.Microbes in Elemental CyclesIn the carbon cycle, microorganisms decompose organic matter, releasing carbon dioxide via aerobic respiration. This carbon dioxide is subsequently used by photosynthetic organisms to synthesize organic compounds, closing the...
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Microbial growth control refers to various methods employed to inhibit, reduce, or eliminate microorganisms to ensure safety and hygiene across different settings. These methods are categorized based on the target environment and the level of microbial control required.Biocides are versatile agents designed to control microorganisms by either inhibiting their growth or outright killing them. These agents work through various physical, chemical, mechanical, or biological mechanisms. The...
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Updated: Nov 21, 2025

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials
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Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

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Living materials with programmable functionalities grown from engineered microbial co-cultures.

Charlie Gilbert1,2, Tzu-Chieh Tang3,4,5, Wolfgang Ott1,2

  • 1Imperial College Centre for Synthetic Biology, Imperial College London, London, UK.

Nature Materials
|January 12, 2021
PubMed
Summary
This summary is machine-generated.

Researchers created new living materials using yeast and bacteria. These materials can be programmed to act as catalysts or sensors, opening doors for advanced biosensing and biocatalysis applications.

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Area of Science:

  • Biomaterials Engineering
  • Synthetic Biology
  • Microbiology

Background:

  • Biological systems exhibit self-patterning, self-repair, and environmental sensing capabilities.
  • Engineered living materials (ELMs) aim to replicate natural biomaterial properties using genetically modified organisms.
  • Bacterial cellulose (BC) is a natural biomaterial with unique properties.

Purpose of the Study:

  • To develop a novel platform for fabricating functional bacterial cellulose-based engineered living materials.
  • To explore the use of a stable co-culture of Saccharomyces cerevisiae yeast and Komagataeibacter rhaeticus bacteria for material fabrication.
  • To demonstrate the potential for creating autonomously catalytic and responsive living materials.

Main Methods:

  • Utilized a stable co-culture of Saccharomyces cerevisiae and Komagataeibacter rhaeticus.
  • Engineered yeast strains to secrete enzymes into the bacterial cellulose matrix.
  • Incorporated engineered yeast directly within the growing cellulose matrix.
  • Investigated DNA-encoded modification of bacterial cellulose properties.

Main Results:

  • Successfully fabricated bacterial cellulose-based living materials.
  • Demonstrated yeast secretion of enzymes for autonomously grown catalytic materials.
  • Enabled DNA-encoded modification of bacterial cellulose bulk properties.
  • Created living materials capable of sensing and responding to chemical and optical stimuli.

Conclusions:

  • A symbiotic co-culture of yeast and bacteria provides a flexible platform for producing engineered living materials.
  • These BC-based ELMs offer potential applications in biosensing and biocatalysis.
  • The developed approach enables the creation of functional, responsive, and customizable living materials.