Related Experiment Video
Updated: Nov 21, 2025

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Glutathione-Responsive Polymeric Micelles Formed by a Biodegradable Amphiphilic Triblock Copolymer for Anticancer
Zhigang Xu1, Shiying Liu1, Yuejun Kang1
1School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459, Singapore.
Abstract:
This article presents a novel glutathione (GSH)-responsive poly(ethylene glycol)-b-polycarbonate-b-poly(ethylene glycol) triblock copolymer that self-assembles into micellar nanoparticles and simutaneously carry hydrophobic anticancer drugs such as doxirubicin. These drug-loading micelles show glutathione-triggered decomposition that leads to controlled drug release and cytotoxicity to cancer cells. This polymeric drug-carrier system integrates features of facile synthesis, stimuli-responsive drug release, good biocompatibility, and relatively low toxicity of the dissociated segments, thus representing a promising anticancer drug carrier for potential clinical applications.
Related Concept Videos
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Drugs that Stabilize Microtubules

