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Biomedical Applications of Graphene Nanomaterials and Beyond
Krishanu Ghosal1, Kishor Sarkar1
1Gene Therapy and Tissue Engineering Lab, Department of Polymer Science & Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, India.
ACS Biomaterials Science & Engineering
|January 13, 2021
Summary
Graphene nanomaterials offer unique properties for diverse bioapplications like drug delivery and biosensing. This review details their synthesis, biomedical uses, biocompatibility, risks, and future clinical potential.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Graphene nanomaterials possess exceptional properties: structural, optical, thermal, electrical, and mechanical.
- Their unique characteristics enable extensive research in electronics, energy, catalysis, sensing, and biomedical fields.
- Graphene-based nanomaterials are increasingly used in drug/gene delivery, biosensing, tissue engineering, bioimaging, and therapies.
Purpose of the Study:
- To review synthesis methods for graphene oxide (GO), reduced graphene oxide (rGO), and graphene quantum dots (GQDs).
- To highlight the diverse biomedical applications of graphene nanomaterials.
- To discuss the biocompatibility and potential risks of graphene nanomaterials in bioapplications.
Main Methods:
- Review of synthesis procedures for graphene family nanomaterials.
- Compilation of current research on biomedical applications.
- Analysis of biocompatibility and safety data.
Main Results:
- Graphene nanomaterials exhibit excellent aqueous processability, surface functionalizability, and tunable properties.
- Key applications include drug delivery, biosensing, tissue engineering, bioimaging, and photothermal/photodynamic therapies.
- Biocompatibility and potential risks are crucial considerations for clinical translation.
Conclusions:
- Graphene nanomaterials show significant promise for advanced biomedical applications.
- Further research is needed to address challenges and optimize for clinical use.
- Understanding synthesis, applications, and safety is vital for future development.
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