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Mapping the orbitofrontal cortex using temporal fluctuations in cerebral blood flow.

Kalen J Petersen1,2, Manus J Donahue1,2,3, Daniel O Claassen2

  • 1Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.

Brain and Behavior
|January 13, 2021
PubMed
Summary
This summary is machine-generated.

This study used novel arterial spin labeling (ASL) to map functional connectivity in the orbitofrontal cortex (OFC). The results confirm distinct medial-lateral and rostral-caudal OFC divisions, offering a clearer view of brain organization.

Keywords:
functional MRImagnetic resonance imagingneuroanatomyneuroimaging

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Area of Science:

  • Neuroscience
  • Neuroimaging
  • Brain Mapping

Background:

  • The orbitofrontal cortex (OFC) plays a crucial role in decision-making and behavior.
  • Traditional MRI methods for studying the OFC are limited by susceptibility artifacts.
  • Existing anatomical studies suggest OFC organization along medial-lateral and rostral-caudal axes.

Purpose of the Study:

  • To test if OFC topology reflects correlated temporal hemodynamic activity using a novel functional connectivity approach.
  • To overcome limitations of susceptibility-weighted imaging in the inferior frontal lobes.
  • To provide in vivo cortical parcellation of the OFC based on perfusion fluctuations.

Main Methods:

  • Utilized 3D perfusion-weighted arterial spin labeling (ASL) functional connectivity.
  • Acquired ASL scans in 20 healthy participants.
  • Applied k-means clustering to model ASL-based connectivity and assess reproducibility.

Main Results:

  • Confirmed medial-lateral and rostral-caudal OFC divisions, supporting the initial hypothesis.
  • Demonstrated high reproducibility with 84% voxel clustering agreement between sessions for the k=2 solution.
  • Showcased the utility of ASL for mapping OFC functional subdivisions.

Conclusions:

  • This study presents the first in vivo cortical parcellation of the OFC based on perfusion fluctuations.
  • The findings validate anatomical predictions of OFC functional subdivisions.
  • The ASL approach offers a less susceptibility-sensitive alternative to conventional methods for OFC research.