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Updated: Nov 21, 2025

Using an Automated Cell Counter to Simplify Gene Expression Studies: siRNA Knockdown of IL-4 Dependent Gene Expression in Namalwa Cells
Published on: April 14, 2010
[The role of IL4I1 in immunoregulation: An update]
Wenqian Liu1, Chengya Dong1, Xiangrong Liu2
1National Center of Clinical Medicine for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Abstract:
Interleukin-4 induced 1 protein (IL4I1), a secreted amino acid oxidase produced by antigen presenting cells, oxidizes phenylalanine to phenylpyruvate. It has been found that IL4I1 exerts an immunosuppressive function by inhibiting the proliferation and differentiation of T cells as well as limiting the proliferation of B cells. IL4I1 is involved in host defense against infection. As a gene related to poor prognosis in cancers, IL4I1 participates in tumor immune escape. IL4I1 promotes remyelination via regulation of the different phenotypes of microglia in the autoimmune demyelinating diseases, but the detailed mechanism still remains unknown. We summarize the role and mechanism of IL4I1 in the immune regulation to provide new ideas for the treatment of infections, cancers and autoimmune diseases.
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