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A Convenient Method for Extraction and Analysis with High-Pressure Liquid Chromatography of Catecholamine Neurotransmitters and Their Metabolites
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Reply to Pan et al.: Whole blood metabolome analysis combined with comprehensive frailty assessment

Masahiro Kameda1, Takayuki Teruya2, Mitsuhiro Yanagida3

  • 1Geriatric Unit, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.

Proceedings of the National Academy of Sciences of the United States of America
|January 14, 2021
PubMed
Abstract

No abstract available in PubMed .

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Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...

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