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Hydroxycinnamic acids on gut microbiota and health
William Leonard1, Pangzhen Zhang1, Danyang Ying2
1School of Agriculture and Food, The University of Melbourne, Parkville, Victoria, Australia.
Comprehensive Reviews in Food Science and Food Safety
|January 14, 2021
Summary
Hydroxycinnamic acids (HCAs) are phenolic compounds impacting gut microbiota. This review explores HCA metabolism, interactions with gut microbes, and links to diseases like colorectal cancer and obesity.
Area of Science:
- * Nutrition Science
- * Microbiology
- * Human Health
Background:
- * Hydroxycinnamic acids (HCAs) are phenolic compounds with a phenylpropanoid backbone.
- * Often overlooked compared to flavonoids, HCAs' role in human health is gaining attention.
- * Recent research focuses on polyphenol-gut microbiota interactions and their health implications.
Purpose of the Study:
- * To review the metabolism of HCAs in the digestive tract.
- * To explore the interactions between HCAs and gut microbiota.
- * To link HCA-gut microbiota interactions to various human diseases and conditions.
Main Methods:
- * Comprehensive literature review of existing studies.
- * Analysis of animal model studies on HCA's gut microbiota-modulating effects.
- * Examination of factors influencing HCA bioavailability and interactions.
Main Results:
- * HCAs undergo metabolism in the digestive tract, influencing gut microbiota composition.
- * HCA-gut microbiota interactions are linked to colorectal cancer, IBD, cognitive impairments, NAFLD, and obesity.
- * Food matrix and processing significantly affect HCA bioavailability and microbial interactions.
Conclusions:
- * HCAs play a crucial role in modulating gut microbiota, impacting human health.
- * Further research is needed to elucidate specific mechanisms and identify therapeutic potentials.
- * Understanding HCA-gut microbiota dynamics offers insights into disease prevention and management.
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