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Breast-implant-associated anaplastic large-cell lymphoma
S Ozalla Samaniego1, G Meijide Santos2, M Soto Dopazo3
1Unidad de Mama, Servicio de Radiodiagnóstico, Hospital Universitario de Cabueñes, Gijón, España.
Radiologia
|January 15, 2021
Summary
Breast-implant-associated anaplastic large-cell lymphoma (BIA-ALCL) is a rare cancer linked to textured breast implants. Early diagnosis via fluid analysis and implant removal offers a good prognosis for patients with BIA-ALCL.
Area of Science:
- Oncology
- Pathology
- Medical Devices
Background:
- Breast-implant-associated anaplastic large-cell lymphoma (BIA-ALCL) is a rare T-cell lymphoma.
- It is exclusively associated with textured breast implants, typically presenting years after implantation.
- Common presentations include peri-implant effusion or a palpable mass.
Purpose of the Study:
- To present a case of BIA-ALCL with both effusion and a nodule.
- To highlight diagnostic and management strategies for BIA-ALCL.
- To emphasize the importance of multidisciplinary care and regulatory notification.
Main Methods:
- Diagnosis of BIA-ALCL confirmed by cytological and histological analysis.
- Ultrasound-guided fine-needle aspiration for effusion.
- Core-needle biopsy for suspected masses.
- Surgical removal of implants and capsulectomy.
Main Results:
- The case presented with peri-implant effusion and an incipient nodule in a patient with textured implants.
- Immunophenotyping showed CD30 expression and ALK negativity.
- Treatment involved implant removal and bilateral capsulectomy.
Conclusions:
- BIA-ALCL requires a multidisciplinary approach involving oncologists, surgeons, and pathologists.
- Prompt diagnosis and treatment, including implant removal, are crucial.
- Notification to regulatory agencies like the Spanish Agency of Medicines and Medical Devices (AEMPS) is essential for disease surveillance.
