Related Experiment Video
Updated: Nov 21, 2025
Separation of Rat Epidermis and Dermis with Thermolysin to Detect Site-Specific Inflammatory mRNA and Protein
Published on: September 29, 2021
Study of Translocation of Stabilized NO Forms through Rat Skin using Electron Paramagnetic Resonance Method
A A Timoshin1, K B Shumaev2,3, V L Lakomkin2
1National Medical Research Centre for Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia. timoshin_a_a@mail.ru.
Abstract:
We studied the effect of dinitrosyl-iron complexes with N-acetyl-L-cysteine as a thiol-containing ligand (DNIC-Acc) after transdermal administration to rats. Electron paramagnetic resonance spectroscopy with a lipophilic NO spin trap (a complex of iron and diethyldithiocarbamate ions) showed that DNIC-Acc administration significantly increased the total level of NO in the lung and liver tissues of the animal, which was accompanied by a slight decrease in the mean BP (<10%).
