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Updated: Nov 21, 2025
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Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
Published on: April 8, 2016
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Cytokines in psoriasis
Camila Cataldi de Alcantara1, Edna Maria Vissoci Reiche2, Andréa Name Colado Simão2
1Research Laboratory in Applied Immunology, State University of Londrina, Paraná, Brazil.
Advances in Clinical Chemistry
|January 17, 2021
Summary
Psoriasis is a chronic inflammatory skin disease driven by immune cells and cytokines. The T helper 17 (Th17) cytokine family plays a key role in its pathogenesis, influencing disease activity and treatment challenges.
Area of Science:
- Immunodermatology
- Molecular biology
- Genetics
Background:
- Psoriasis is a chronic, immune-mediated inflammatory skin disease with complex origins.
- It manifests as dry, scaly lesions on the skin.
- The pathophysiology involves a network of immune cells and cytokines.
Purpose of the Study:
- To clarify the mechanisms of cytokine involvement in psoriasis pathophysiology.
- To understand how this knowledge translates to medical practice.
- To address the clinical heterogeneity and treatment challenges in psoriasis.
Main Methods:
- Review of current understanding of psoriasis pathophysiology.
- Analysis of the role of T helper (Th)17 cytokines.
- Examination of genetic variations influencing cytokine expression.
Main Results:
- The T helper 17 (Th17) cytokine family is now recognized as a major effector in psoriatic disease pathogenesis.
- Cytokine networks significantly influence the inflammatory patterns during disease activity.
- Genetic variations contribute to clinical heterogeneity, complicating drug development.
Conclusions:
- Understanding cytokine mechanisms is crucial for advancing psoriasis treatment.
- The Th17 pathway is a critical target for therapeutic interventions.
- Further research is needed to translate mechanistic insights into effective clinical practice.
Keywords:
AdipokinesCytokinesCytokines genetic variantsCytokines in treatmentPsoriasisTh1 cytokinesTh17 cytokinesTh2 cytokinesTreg cytokinesMore Related Videos
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