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Small interfering RNAs in tendon homeostasis.
Giuseppe Gargano1,2, Antonio Oliviero1,2, Francesco Oliva1,2
1Department of Trauma and Orthopaedic Surgery, AOU San Giovanni di Dio e Ruggi D'Aragona, Via San Leonardo 1, 84131 Salerno, Italy.
British Medical Bulletin
|January 17, 2021
Summary
Small interfering RNAs (siRNAs) show potential in regulating genes for tendon healing and identifying therapeutic targets. Further research is needed to clarify their direct role in facilitating tendon repair processes.
Area of Science:
- Biochemistry
- Molecular Biology
- Regenerative Medicine
Background:
- Tendon structure and homeostasis rely on genes encoding fibrous proteins.
- Small interfering RNAs (siRNAs) modulate gene expression, suggesting a role in tendon repair.
Purpose of the Study:
- To explore the potential of siRNAs in studying tendon healing.
- To identify therapeutic targets for tendon repair using gene regulation.
Main Methods:
- Systematic literature search of multiple databases up to October 2020.
- Analysis of 17 selected studies on siRNA and tendon healing.
Main Results:
- siRNAs can regulate genes and growth factors involved in tendinopathy and tendon healing.
- The precise gene silencing effects of siRNAs in tendon repair remain unclear.
Conclusions:
- siRNAs offer a valuable tool for investigating tendon healing mechanisms.
- Further research is required to establish direct siRNA actions for facilitating tendon repair.
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