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New Insights Into Pentosan Polysulfate Maculopathy
Ophthalmic Surgery, Lasers & Imaging Retina
|January 20, 2021
Summary
Pentosan polysulfate (PPS) maculopathy shows increased choriocapillaris flow voids and progressive retinal thinning. Dark adaptometry was delayed, suggesting potential secondary retinal effects from PPS toxicity.
Area of Science:
- Ophthalmology
- Toxicology
- Retinal Imaging
Background:
- Pentosan polysulfate (PPS) is used for interstitial cystitis.
- Maculopathy has been reported as a potential adverse effect of long-term PPS use.
Purpose of the Study:
- To investigate the multimodal imaging and functional characteristics of toxic maculopathy secondary to pentosan polysulfate (PPS).
Main Methods:
- Retrospective case-series of four patients with PPS maculopathy.
- Utilized multimodal imaging (OCT angiography), electrophysiology, dark adaptometry (DA), and genetic testing.
Main Results:
- Increased choriocapillaris flow voids (54.25%) observed on OCT angiography compared to controls (13.2%).
- Two patients showed abnormal foveal avascular zones and progressive retinal thinning.
- Dark adaptometry was delayed in 2/2 patients, while electrophysiology was normal in 3/3.
Conclusions:
- Novel findings of PPS maculopathy include choriocapillaris flow voids and progressive retinal thinning.
- These findings enhance understanding of the pathophysiology of PPS-induced retinal toxicity.
