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Renal Diffusion-Weighted Imaging (DWI) for Apparent Diffusion Coefficient (ADC), Intravoxel Incoherent Motion (IVIM),
Neil Peter Jerome1,2, Anna Caroli3, Alexandra Ljimani4
1Institute for Circulation and Diagnostic Imaging, Norwegian University of Science and Technology (NTNU), Trondheim, Norway. neil.p.jerome@ntnu.no.
Methods in Molecular Biology (Clifton, N.J.)
|January 21, 2021
Summary
Diffusion-weighted imaging (DWI) reveals kidney microstructure by tracking water molecule motion. This technique offers insights into renal function and disease in animal models.
Area of Science:
- Biomedical Engineering
- Medical Imaging
- Renal Physiology
Background:
- Kidney function relies on unique microstructural organization.
- Altered renal blood flow and filtration are key indicators of kidney disease.
- Diffusion-weighted imaging (DWI) is sensitive to water molecule diffusion within tissues.
Purpose of the Study:
- To introduce Diffusion-weighted imaging (DWI) concepts and applications for renal research.
- To provide an overview of DWI acquisition strategies and analytical models.
- To highlight DWI's utility in studying animal models of kidney disease.
Main Methods:
- Introduction to fundamental Diffusion-weighted imaging (DWI) principles.
- Review of common DWI acquisition schemes and analytical models.
- Exploration of DWI applications in preclinical renal disease models.
Main Results:
- DWI sensitizes MRI signals to water molecule motion, reflecting tissue microstructure complexity.
- Various DWI strategies and models can capture diffusion, perfusion, compartmentalization, and anisotropy.
- DWI shows promise for investigating kidney function and disease.
Conclusions:
- Diffusion-weighted imaging (DWI) is a valuable tool for assessing kidney microstructure and function.
- Understanding DWI principles and models is crucial for its effective application in renal research.
- DWI facilitates the study of renal pathophysiology in animal models, contributing to biomarker development.
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