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Renal pH Imaging Using Chemical Exchange Saturation Transfer (CEST) MRI: Basic Concept.

Dario Livio Longo1, Pietro Irrera2, Lorena Consolino3

  • 1Institute of Biostructures and Bioimaging (IBB), Italian National Research Council (CNR), Torino, Italy. dariolivio.longo@cnr.it.

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Summary
This summary is machine-generated.

Chemical exchange saturation transfer (CEST) MRI offers advanced insights into kidney function and pH. This technique aids in diagnosing kidney diseases and monitoring conditions like renal injury and transplant rejection.

Keywords:
Acute kidney injuryChemical exchange saturation transfer (CEST)IopamidolIschemia–reperfusion injuryKidneyMagnetic resonance imaging (MRI)MiceRatsRenal damagepH

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Area of Science:

  • Biomedical Imaging
  • Renal Physiology
  • Medical Diagnostics

Background:

  • Magnetic Resonance Imaging (MRI) is established for renal function assessment.
  • Chemical Exchange Saturation Transfer (CEST) MRI is an emerging technique for enhanced functional renal insights.
  • CEST MRI utilizes endogenous and exogenous agents to probe kidney physiology.

Purpose of the Study:

  • To review CEST MRI procedures for assessing kidney functionality and pH.
  • To highlight CEST MRI's role in monitoring renal pH in disease models.
  • To evaluate CEST MRI for assessing renal allograft rejection.

Main Methods:

  • Review of preclinical and clinical studies employing CEST MRI for renal applications.
  • Focus on CEST MRI techniques for measuring glomerular filtration rate, renal plasma flow, oxygenation, and diffusion.
  • Exploration of CEST MRI for acid-base homeostasis and pH monitoring in the kidney.

Main Results:

  • CEST MRI provides detailed physiological information beyond conventional MRI.
  • CEST MRI demonstrates potential in assessing acid-base balance and pH dynamics in renal disease models.
  • The technique shows promise for monitoring kidney allograft status.

Conclusions:

  • CEST MRI is a valuable tool for comprehensive renal functional assessment.
  • CEST MRI offers novel insights into kidney pathophysiology and disease progression.
  • Further standardization and application of CEST MRI are crucial for clinical translation in nephrology.