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Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
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Renal Blood Flow Using Arterial Spin Labeling (ASL) MRI: Experimental Protocol and Principles
Kai-Hsiang Chuang1, Martin Meier2, María A Fernández-Seara3
1Queensland Brain Institute and Centre for Advanced Imaging, University of Queensland, Brisbane, QLD, Australia.
Methods in Molecular Biology (Clifton, N.J.)
|January 21, 2021
Summary
Arterial spin labeling (ASL) MRI offers a noninvasive method for measuring kidney perfusion, crucial for understanding kidney physiology and enabling safe, reproducible, longitudinal studies without contrast agents.
Area of Science:
- Medical Imaging
- Physiology
- Biomarkers
Background:
- Accurate measurement of renal perfusion is vital for understanding kidney physiology.
- Noninvasive techniques are preferred for longitudinal and multisite studies.
- Exogenous contrast agents pose safety concerns in medical imaging.
Purpose of the Study:
- To present a noninvasive, robust, and reproducible method for measuring renal perfusion using MRI.
- To highlight the advantages of Arterial Spin Labeling (ASL) MRI in quantitative perfusion assessment.
- To support the standardization of renal MRI biomarkers within the PARENCHIMA COST Action framework.
Main Methods:
- Utilizes Arterial Spin Labeling (ASL) MRI technique.
- Employs endogenous blood water as freely diffusible tracers.
- Quantitatively measures perfusion without exogenous contrast agents.
Main Results:
- ASL MRI provides quantitative tissue perfusion information.
- The method is noninvasive, robust, and reproducible.
- Eliminates safety concerns associated with gadolinium chelates.
Conclusions:
- ASL MRI is a valuable tool for quantitative renal perfusion measurement.
- This technique is suitable for multisite and longitudinal imaging of living subjects.
- The presented protocol contributes to the standardization of renal MRI biomarkers.
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