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Updated: Nov 20, 2025

Myelin Oligodendrocyte Glycoprotein MOG35-55 Induced Experimental Autoimmune Encephalomyelitis EAE in C57BL/6 Mice
Published on: April 15, 2014
Fever is a common onset feature of MOG-IgG associated disorders (MOGAD)
Alexandre Lampros1, Thomas De Broucker1, Mickael Bonnan1
1Service de Neurologie, Centre Hospitalier Delafontaine, Saint-Denis, France.
Background:
Fever is a deceptive feature of autoimmune disorders. Although cases of MOG-IgG associated disorders (MOGAD) were rarely associated with fever, this association was not specifically described.
Methods:
We report a case of MOGAD revealed by weeks of fever and meningitis. We reviewed the current literature to describe the association between fever and MOGAD.
Results:
We analyzed 146 cases from the literature including ours. Fever was associated with 39% of MOGAD attacks and lasted more than a week in 74%. Fever was strongly associated with brain and spinal cord attacks, and with meningitis.
Conclusion:
Among the various features of MOGAD, fever is a highly prevalent associated symptom that should be kept in mind.
Insights
Fever is a common symptom in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disorders (MOGAD), often lasting over a week. This finding highlights fever as a key indicator for MOGAD, especially when accompanied by meningitis or central nervous system attacks.
Area of Science:
- Neuroimmunology
- Neurology
Background:
- Fever is an uncommon yet significant symptom in autoimmune disorders.
- The association between fever and Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disorders (MOGAD) has not been extensively documented.
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