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Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
Published on: February 18, 2022
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Peripapillary Perfused Capillary Density in Acute Angle-Closure Glaucoma: An Optical Coherence Tomography Angiography
Yanin Suwan1, Masoud Aghsaei Fard2, Purit Petpiroon1
1Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Asia-Pacific Journal of Ophthalmology (Philadelphia, Pa.)
|January 22, 2021
Summary
Microvascular changes in resolved acute angle-closure (AAC) eyes are similar to those in primary open-angle glaucoma (POAG) eyes. Peripapillary perfused capillary density (PCD) did not significantly differ between AAC and POAG, regardless of POAG severity.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Microvascular Imaging
Background:
- Acute angle-closure (AAC) and primary open-angle glaucoma (POAG) are distinct glaucoma types.
- Assessing microvascular changes can aid in understanding glaucoma pathophysiology.
Purpose of the Study:
- To compare peripapillary perfused capillary density (PCD) using optical coherence tomography angiography (OCTA).
- To evaluate PCD differences between resolved AAC, POAG, and control eyes.
Main Methods:
- Prospective, cross-sectional, observational study.
- OCTA imaging of the optic nerve head.
- Customized software for PCD analysis with major vessel removal.
- Statistical analysis including ANOVA, Bonferroni correction, and generalized estimating equations.
Main Results:
- Included 44 resolved AAC eyes, 69 POAG eyes, and 49 control eyes.
- Peripapillary perfused capillary density (PCD) showed similar decreases in AAC and POAG eyes (P > 0.99).
- No significant differences in global PCD were found between POAG severity groups and the AAC group after adjustment for age and sex.
Conclusions:
- Microvascular attenuation in resolved AAC eyes is comparable to that in POAG eyes.
- OCTA is a valuable tool for assessing microvascular changes in glaucoma.
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