Exercise and Circulating Microparticles in Healthy Subjects

Area of Science:

• Exercise physiology
• Cardiovascular research
• Cell biology

Background:

• Circulating microparticles (CMPs) are biomarkers of cellular activation and damage.
• Exercise influences hemodynamic forces and cellular function, potentially affecting CMP levels.
• Understanding the exercise-CMPs relationship is crucial for assessing physiological adaptations.

Purpose of the Study:

• To systematically review the existing literature on the relationship between exercise and CMPs.
• To analyze the impact of single-bout and long-term exercise on different types of CMPs.
• To explore potential mechanisms behind exercise-induced changes in CMPs.

Main Methods:

• Systematic literature search of PubMed, Web of Science, Embase, and Cochrane Library databases.
• Inclusion of 26 studies encompassing various designs (RCTs, cohort, case-control, descriptive).
• Assessment of study quality using Cochrane tool and MI$\\text{N}$S.

Main Results:

• Single exercise bouts increase CMPs in untrained subjects; trained subjects show lower CMP levels.
• Platelet-derived microparticles (PMPs) transiently increase post-exercise, with reduced impact in trained individuals.
• Leukocyte-derived microparticles (LMPs) generally decrease in trained subjects after exercise; EMPs and ErMPs show variable changes.

Conclusions:

• Exercise elicits distinct responses in CMP levels based on training status and exercise type.
• Trained individuals exhibit enhanced adaptation to exercise-induced hemodynamic stress, leading to lower CMP levels.
• Further research is needed to fully elucidate the complex interactions between exercise and CMP dynamics.