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Updated: Nov 20, 2025

A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria
Published on: June 27, 2022
Hydrogen sulfide triggered molecular agent for imaging and cancer therapy
Chao Ge1, Xiaojiao Di1, Siqi Han2
1School of Chemistry and Materials Science, Jiangsu Key Laboratory of Biofunctional Materials, Nanjing Normal University, Nanjing, 210023, P. R. China. liuhongke@njnu.edu.cn yongqian@njnu.edu.cn.
Abstract:
We developed an activatable molecular reagent, PNF, triggered by intracellular H2S in the lysosome to release the therapeutic drug amonafide, which can escape from the lysosome into the nucleus to induce autophagy of cancer cells. PNF exhibits potent inhibitory activity against cisplatin-resistant tumor cell lines.
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