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Published on: July 2, 2018
3D Bioprinting of In Vitro Models Using Hydrogel-Based Bioinks
Yeong-Jin Choi1, Honghyun Park1, Dong-Heon Ha2
1Department of Advanced Biomaterials Research, Korea Institute of Materials Science (KIMS), 797, Changwon 51508, Korea.
Insights
3D bioprinting offers a rapid solution for creating advanced in vitro models to combat emerging diseases like COVID-19. This technology aids in developing therapeutic agents and understanding disease pathology effectively.
Area of Science:
- Biotechnology
- Regenerative Medicine
- Pathology
Background:
- The COVID-19 pandemic highlighted the urgent need for rapid development of therapeutic agents.
- Traditional in vitro models face limitations in accurately mimicking human physiology and disease progression.
- Social distancing measures during the pandemic underscored the importance of remote research tools.
Purpose of the Study:
- To provide an in-depth assessment of 3D bioprinting technology and bioinks for in vitro modeling.
- To discuss recent advancements and future prospects of 3D bioprinting in disease research.
- To evaluate the potential of 3D bioprinting in establishing reliable models for emerging infectious diseases.
Main Methods:
- Review and analysis of recent literature on 3D bioprinting techniques and bioink development.
- Assessment of high-precision 3D bioprinting for creating organoid and tissue models.
- Evaluation of the application of 3D bioprinting in validating pathological behaviors and therapeutic agents.
Main Results:
- 3D bioprinting enables the creation of sophisticated in vitro models that replicate human organ and tissue functions.
- Advancements in bioinks and printing resolution enhance the fidelity of these models.
- These models show promise in accelerating the identification and validation of therapeutic agents for diseases like COVID-19.
Conclusions:
- 3D bioprinting is a transformative technology for developing advanced in vitro models for rapid response to emerging diseases.
- The technology facilitates the study of pathogen behavior and the testing of potential therapeutics.
- Continued innovation in 3D bioprinting and bioinks will be crucial for future infectious disease research and drug discovery.
Abstract:
Coronavirus disease 2019 (COVID-19), which has recently emerged as a global pandemic, has caused a serious economic crisis due to the social disconnection and physical distancing in human society. To rapidly respond to the emergence of new diseases, a reliable in vitro model needs to be established expeditiously for the identification of appropriate therapeutic agents. Such models can be of great help in validating the pathological behavior of pathogens and therapeutic agents. Recently, in vitro models representing human organs and tissues and biological functions have been developed based on high-precision 3D bioprinting. In this paper, we delineate an in-depth assessment of the recently developed 3D bioprinting technology and bioinks. In particular, we discuss the latest achievements and future aspects of the use of 3D bioprinting for in vitro modeling.
