Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Developmental dynamics of symptoms of emotional problems in childhood and adolescence: A longitudinal network analysis.

JCPP advances·2026
Same author

Using EEG to Measure the Neural Effects of Oxytocin Administration: A Meta-Analysis and Systematic Review.

Psychophysiology·2026
Same author

An automated quantitative report for multiple sclerosis using only 3D T2-fluid-attenuated inversion recovery MRI.

Neuroradiology·2026
Same author

Cardiometabolic Risk and Structural Brain Development in a Large Community-Based US Cohort.

Human brain mapping·2026
Same author

Cerebral cortical alterations in adolescent early-onset psychosis: a surface-based morphometry mega-analysis.

Molecular psychiatry·2026
Same author

Individualized cortical gradient and network topology reveal symptom-linked disruptions and neurobiological subtypes in schizophrenia.

medRxiv : the preprint server for health sciences·2026

Related Experiment Video

Updated: Nov 19, 2025

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
10:33

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

8.8K

Apolipoprotein ɛ4 Status and Brain Structure 12 Months after Mild Traumatic Injury: Brain Age Prediction Using Brain

Torgeir Hellstrøm1, Nada Andelic1,2, Ann-Marie G de Lange3,4,5

  • 1Department of Physical Medicine and Rehabilitation, Oslo University Hospital, 0424 Oslo, Norway.

Journal of Clinical Medicine
|January 27, 2021
PubMed
Summary

The Apolipoprotein E (APOE) ɛ4 gene variant may indicate reduced neuronal integrity in the cingulum following mild traumatic brain injury (MTBI). Further research is needed to confirm this association in larger patient cohorts.

Keywords:
APOEMRIbrain-age gapmild traumatic brain injury

More Related Videos

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging
08:27

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging

Published on: April 11, 2025

678
Electromagnetic Controlled Closed-Head Model of Mild Traumatic Brain Injury in Mice
09:07

Electromagnetic Controlled Closed-Head Model of Mild Traumatic Brain Injury in Mice

Published on: September 28, 2022

2.5K

Related Experiment Videos

Last Updated: Nov 19, 2025

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
10:33

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

8.8K
Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging
08:27

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging

Published on: April 11, 2025

678
Electromagnetic Controlled Closed-Head Model of Mild Traumatic Brain Injury in Mice
09:07

Electromagnetic Controlled Closed-Head Model of Mild Traumatic Brain Injury in Mice

Published on: September 28, 2022

2.5K

Area of Science:

  • Neuroscience
  • Genetics
  • Radiology

Background:

  • Apolipoprotein E (APOE) ɛ4 allele is linked to adverse outcomes in moderate-to-severe traumatic brain injury (TBI).
  • Limited research exists on APOE ɛ4's impact on intracranial pathology after mild traumatic brain injury (MTBI).
  • This study investigates APOE ɛ4's association with advanced MRI metrics in MTBI patients.

Purpose of the Study:

  • To explore the relationship between APOE ɛ4 status and MRI-derived brain age prediction.
  • To assess the influence of APOE ɛ4 on brain morphometry and diffusion tensor imaging (DTI) measures post-MTBI.
  • To identify potential neurobiological differences associated with APOE ɛ4 carriage in MTBI survivors.

Main Methods:

  • Inclusion of patients aged 16-65 with acute MTBI.
  • Multimodal MRI acquisition at 12 months post-injury, correlated with APOE ɛ4 genotyping.
  • Statistical analysis incorporating false discovery rate (FDR) for multiple comparisons.

Main Results:

  • 123 MTBI patients with complete APOE, volumetric, and DTI data were analyzed.
  • No significant demographic or clinical differences were observed between APOE ɛ4 carriers and non-carriers.
  • Brain age prediction models (DTI-based and morphometry-based) showed high accuracy, but no significant group differences in brain-age gap.
  • APOE ɛ4 carriers exhibited trends towards lower fractional anisotropy (FA) in the cingulum bundle, but this did not reach statistical significance after FDR correction.

Conclusions:

  • APOE ɛ4 carriers may exhibit subtle reductions in neuronal integrity within the cingulum post-MTBI.
  • Larger cohort studies are recommended to validate these preliminary findings.
  • The study highlights the potential role of APOE ɛ4 in MTBI-related neurobiological changes.