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A Perspective on Innovating the Chemistry Lab Bench.

Alexander G Godfrey1, Samuel G Michael1, Gurusingham Sitta Sittampalam1

  • 1National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, United States.

Frontiers in Robotics and AI
|January 27, 2021
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Summary

This perspective proposes a sustainable, automated chemistry bench standard by integrating advanced automation, synthetic, analytical, and information technologies, alongside artificial intelligence/machine learning (AI/ML) for enhanced scientific discovery.

Keywords:
automated chemical synthesisbench chemistryreaction planningreagent deliveryretrosynthetic analysis

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Area of Science:

  • Chemistry
  • Laboratory Automation
  • Artificial Intelligence

Background:

  • The chemical bench is a critical area for scientific discovery, yet its design and function present ongoing challenges.
  • A first-principles approach is needed to address current limitations in bench work.

Purpose of the Study:

  • To explore the design and creation of a sustainable new standard for an advanced automated chemistry bench.
  • To propose a framework for integrating modern technologies to maximize data value and system utility.

Main Methods:

  • Leveraging recent advances in laboratory automation.
  • Integrating synthetic, analytical, and information technologies.
  • Incorporating artificial intelligence/machine learning (AI/ML) algorithms.

Main Results:

  • A proposed framework for an automated chemistry bench that maximizes data value.
  • Enhanced utility of laboratory systems through technological integration.
  • Potential for broader application beyond therapeutic molecule design.

Conclusions:

  • The proposed automated chemistry bench design offers a sustainable standard for scientific advancement.
  • This integrated approach can significantly improve efficiency and data generation in chemical research.
  • The system's applicability extends to diverse fields such as materials science, food development, and agriculture.