Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

4.8K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
4.8K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

3.3K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.3K
The Functions of the Skeletal System01:22

The Functions of the Skeletal System

5.3K
The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
5.3K
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

7.3K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
7.3K
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

9.2K
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
9.2K
Bone Remodeling01:40

Bone Remodeling

39.5K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
39.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Continuous subcutaneous recombinant PTH(1-34) infusion improves serum calcium and phosphate homeostasis in children with autosomal dominant hypocalcemia type 1 refractory to standard-of-care treatment.

European journal of endocrinology·2026
Same author

The use of denosumab in rare bone diseases in adults: a systematic review from the ECTS Rare Bone Disease Action Group.

The Journal of clinical endocrinology and metabolism·2026
Same author

Clinical Course of Hyperostosis Due to SP7 (Osterix) Gain-of Function Mutation.

Klinische Padiatrie·2026
Same author

Lower Limb Deformity in Different Types of Rickets.

Journal of clinical medicine·2025
Same author

EndoCompass Project: Research Roadmap for Calcium and Bone Endocrinology.

Hormone research in paediatrics·2025
Same author

Bone Health in Young Individuals with Primary Ciliary Dyskinesia: Insights from a Comparison with Cystic Fibrosis and Healthy Controls.

Hormone research in paediatrics·2025
Same journal

Necrotizing fasciitis of the thigh-a devastating sign of intestinal perforation.

Wiener medizinische Wochenschrift (1946)·2026
Same journal

Regenerative therapies in rehabilitation with interfaces with occupational medicine, geriatrics, and oncology: the example of extracorporeal shock wave therapy.

Wiener medizinische Wochenschrift (1946)·2026
Same journal

Cerebral toxoplasmosis in patients with peripheral B-cell lymphoma : A case series and a literature review.

Wiener medizinische Wochenschrift (1946)·2026
Same journal

Post-pandemic rebound of rotavirus and adenovirus in pediatric gastroenteritis: a 6-year antigen-based surveillance study from Turkey.

Wiener medizinische Wochenschrift (1946)·2026
Same journal

Neuroaxis involvement in Chikungunya virus infection: a retrospective case series.

Wiener medizinische Wochenschrift (1946)·2026
Same journal

A complicated case of a spinal Scedosporium apiospermum infection with a favorable outcome-case report.

Wiener medizinische Wochenschrift (1946)·2026
See all related articles

Related Experiment Video

Updated: Nov 19, 2025

Culturing and Measuring Fetal and Newborn Murine Long Bones
06:58

Culturing and Measuring Fetal and Newborn Murine Long Bones

Published on: April 26, 2019

8.4K

Bone and growth: basic principles behind rare disorders.

Adalbert Raimann1,2, Diana-Alexandra Ertl1,2, Gabriele Haeusler3,4

  • 1Department of Pediatrics and Adolescent Medicine, Division of Pediatric Pulmonology, Allergology and Endocrinology, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria.

Wiener Medizinische Wochenschrift (1946)
|January 27, 2021
PubMed
Summary
This summary is machine-generated.

Rare bone disorders stem from complex molecular and regulatory pathways affecting skeletal development and homeostasis. Understanding these basic principles is key to classifying and addressing conditions impacting bone stability and growth.

Keywords:
Bone fragilityBone regulationMineralizationRare bone disorderRare calcium disorders

More Related Videos

Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification
07:23

Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification

Published on: December 3, 2016

12.2K
Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

86.2K

Related Experiment Videos

Last Updated: Nov 19, 2025

Culturing and Measuring Fetal and Newborn Murine Long Bones
06:58

Culturing and Measuring Fetal and Newborn Murine Long Bones

Published on: April 26, 2019

8.4K
Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification
07:23

Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification

Published on: December 3, 2016

12.2K
Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

86.2K

Area of Science:

  • Skeletal Biology
  • Developmental Biology
  • Endocrinology

Background:

  • Bone health and stature are regulated by numerous molecules and complex pathways.
  • Heterogeneity in rare bone disorders arises from these intricate biological mechanisms.
  • Understanding bone homeostasis is crucial for comprehending skeletal pathologies.

Purpose of the Study:

  • To summarize fundamental principles of bone homeostasis.
  • To provide theoretical background on skeletal development, structure, and regulation.
  • To aid in understanding rare bone disorder classifications.

Main Methods:

  • Literature review and synthesis of existing knowledge on bone biology.
  • Focus on developmental, structural, and regulatory aspects of the skeleton.
  • Categorization of disorders based on affected physiological processes.

Main Results:

  • Detailed overview of molecular and regulatory pathways governing bone health.
  • Explanation of how disruptions in these pathways lead to diverse rare bone disorders.
  • Summary of key principles in skeletal development and homeostasis.

Conclusions:

  • The complexity of molecular regulation underlies the heterogeneity of rare bone disorders.
  • A foundational understanding of bone biology is essential for diagnosing and managing these conditions.
  • This review provides a framework for understanding disorders of bone stability, growth, and mineral metabolism.