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Association between the TAP1 gene polymorphisms and recurrent respiratory papillomatosis in patients from Western

Jaime Palomares-Marin1, Luis Humberto Govea-Camacho2, Vania Araujo-Caballero2

  • 1Departamento de Microbiología y Patología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, México.

Journal of Clinical Laboratory Analysis
|January 28, 2021
PubMed
Abstract

Insights

The G allele in the TAP1 rs1135216 gene polymorphism is linked to an increased genetic risk of developing recurrent respiratory papillomatosis (RRP). This finding is significant for understanding RRP susceptibility in certain populations.

Area of Science:

  • Immunogenetics
  • Virology
  • Respiratory Medicine

Background:

  • Recurrent respiratory papillomatosis (RRP) is a disease caused by human papillomavirus (HPV), primarily genotypes 6 and 11.
  • TAP1 gene polymorphisms may affect immune responses to viral infections and tumors.
  • Previous research suggests TAP1 polymorphisms are associated with susceptibility to immune, infectious, and tumor-related diseases.

Purpose of the Study:

  • To investigate the association between TAP1 single nucleotide polymorphisms (SNPs), specifically rs1057141 and rs1135216, and the risk of RRP.
  • To determine if specific genetic variations in TAP1 influence susceptibility to RRP in a Western Mexican population.

Main Methods:

  • A case-control study involving 35 RRP patients and 35 healthy controls.
  • Histology and PCR were used for RRP diagnosis, HPV genotyping, and viral load determination.
  • Real-time PCR and Arlequin 3.5 software were employed for SNP and haplotypic analyses of rs1057141 and rs1135216.

Main Results:

  • HPV-6 and HPV-11 were identified as the causative genotypes in the studied RRP cases.
  • No significant association was found for the TAP1 rs1057141 polymorphism (p=0.049).
  • A significant association was observed for the TAP1 rs1135216 polymorphism, particularly the G allele, across allelic, dominant, codominant, and additive models (p<0.05).

Conclusions:

  • The G allele of the TAP1 rs1135216 polymorphism is associated with an increased genetic risk of susceptibility to RRP.
  • This finding highlights the role of specific TAP1 gene variations in RRP development within the studied population.
  • Further research may elucidate the precise mechanisms linking TAP1 rs1135216 to RRP pathogenesis.
Keywords:
TAP1HPVlarynxpediatric respiratory papillomatosisrecurrent respiratory papillomatosis

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