Related Experiment Video
Updated: Nov 19, 2025
10:31
Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
444
Therapeutic transformation for diabetic kidney disease
Katherine R Tuttle1, David Z I Cherney2
1Providence Medical Research Center, Providence Health Care, Spokane, Washington, USA; Institute of Translational Health Sciences, Kidney Research Institute, and Nephrology Division, University of Washington, Seattle, Washington, USA.
Kidney International
|January 29, 2021
Summary
Sodium glucose cotransporter 2 (SGLT2) inhibitors significantly reduce kidney and heart failure risks in diabetic kidney disease. Combining SGLT2 inhibitors with endothelin A receptor antagonists may offer enhanced kidney protection.
Area of Science:
- Nephrology
- Cardiology
- Endocrinology
Background:
- Diabetic kidney disease (DKD) poses significant risks for kidney and heart failure.
- Sodium-glucose cotransporter 2 (SGLT2) inhibitors are established treatments for DKD, reducing cardiovascular and renal events.
- Endothelin A receptor antagonism is being investigated for its renoprotective effects in DKD.
Purpose of the Study:
- To evaluate the effect of concomitant SGLT2 inhibitor use during endothelin A receptor antagonism in patients with DKD.
- To assess the combined impact on albuminuria reduction, a marker of kidney damage.
Main Methods:
- Post hoc analysis of the Study of Diabetic Nephropathy with Atrasentan (SONAR) trial.
- Comparison of patients receiving atrasentan with and without concurrent SGLT2 inhibitor therapy during the enrichment period.
Main Results:
- Patients who received SGLT2 inhibitors alongside atrasentan showed a greater reduction in albuminuria compared to those on atrasentan alone.
- This suggests a potential synergistic effect of combined therapies.
Conclusions:
- Combination therapy with SGLT2 inhibitors and endothelin A receptor antagonists may provide superior kidney protection in DKD.
- Further prospective clinical trials are warranted to confirm these findings and explore long-term benefits.
Related Concept Videos
01:28Chronic Kidney Disease III: Interprofessional Care
204
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
204
01:28Kidney Transplant I: Introduction
155
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
155
01:25Chronic Kidney Disease I: Introduction
355
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
355
01:15Diabetes: Management and Pharmacotherapy
707
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
707
01:26Kidney Transplant II: Surgical Procedure
151
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
151
01:16Kidney Transplant III: Nursing Management
172
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
172