Central Serous Chorioretinopathy Analyzed by Multimodal Imaging.

Area of Science:

• Ophthalmology
• Retinal Imaging
• Biochemistry

Background:

• Central serous chorioretinopathy (CSC) is a condition affecting vision.
• Understanding the biochemical changes in CSC is crucial for diagnosis and treatment.

Purpose of the Study:

• To correlate quantitative fundus autofluorescence (qAF) with other fundus features in patients with CSC.
• To investigate the relationship between short wavelength autofluorescence (SW-AF) and CSC pathology.

Main Methods:

• Quantitative fundus autofluorescence (qAF) was used to measure SW-AF (488 nm excitation).
• qAF values were calculated in eight concentric segments (qAF8) at 7°-9° eccentricity.
• Horizontal spectral domain optical coherence tomography (SD-OCT) and near-infrared autofluorescence (NIR-AF) images were analyzed.

Main Results:

• qAF8 measurements did not show a generalizable relationship across CSC eyes.
• Color-coded qAF images revealed altered SW-AF topography and intensity compared to healthy eyes.
• Elevated qAF correlated with retinal pigment epithelial detachment (PED), outer retinal changes, and sub-RPE hypertransmission.
• Decreased qAF was associated with serous retinal detachment and outer retinal degeneration.

Conclusions:

• Localized qAF elevations indicate increased bisretinoid accumulation in CSC lesions.
• Foci of elevated qAF are integral to the natural history of CSC.