Determination of antibiotics in meat samples using analytical methodologies: A review

Area of Science:

• Analytical Chemistry
• Food Safety
• Pharmacology

Background:

• Antibiotics are essential in human and veterinary medicine, but their residues in food pose health risks.
• Regulatory bodies enforce strict maximum residue limits (MRLs) for antibiotics in food products.
• Analyzing antibiotic residues in complex meat matrices presents significant analytical challenges.

Purpose of the Study:

• To comprehensively review methodologies for antibiotic determination in meat samples.
• To cover advancements in sample preparation and determination techniques from 2016 to mid-2020.
• To discuss current trends and future perspectives in antibiotic residue analysis.

Main Methods:

• Review of published literature on antibiotic residue analysis in meat.
• Focus on sample preparation techniques (extraction, cleanup, enrichment).
• Analysis of various sophisticated determination techniques.

Main Results:

• Significant developments in sample preparation and determination methods for antibiotic residues.
• Identification of key challenges in matrix complexity and low detection limits.
• Compilation of methodologies applied to different antibiotic families.

Conclusions:

• Novel methods are continuously needed for accurate antibiotic residue quantification in meat.
• Advancements in analytical techniques are crucial for meeting regulatory requirements.
• Future research should focus on improving efficiency and sensitivity in antibiotic analysis.