Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

X-ray Crystallography02:18

X-ray Crystallography

25.1K
The size of the unit cell and the arrangement of atoms in a crystal may be determined from measurements of the diffraction of X-rays by the crystal, termed X-ray crystallography.
Diffraction
Diffraction is the change in the direction of travel experienced by an electromagnetic wave when it encounters a physical barrier whose dimensions are comparable to those of the wavelength of the light. X-rays are electromagnetic radiation with wavelengths about as long as the distance between neighboring...
25.1K
X-ray Diffraction of Biological Samples01:10

X-ray Diffraction of Biological Samples

4.3K
X-ray diffraction or XRD is an analytical tool that utilizes X-rays to study ordered structures such as crystalline organic and inorganic samples, polycrystalline materials, proteins, carbohydrates, and drugs.
According to Bragg's law, when X-rays strike the sample positioned on a stage, the rays are  scattered by the electron clouds around the sample atoms. The  X-ray diffraction or scattering is caused by constructive interference of the X-ray waves that reflect off the internal...
4.3K
Crystal Growth: Principles of Crystallization01:25

Crystal Growth: Principles of Crystallization

3.8K
Crystallization is a phase transformation process in which crystals are precipitated from a supersaturated solution or formed from other sources. During crystallization, atoms or molecules arrange themselves into a well-defined, rigid crystal lattice to minimize energy.
Initiating crystallization involves manipulating the concentration of the solute and the temperature of the solution. Since crystal growth occurs when the ratio of concentration and solubility of the solute in the solvent...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Visual exoproteomics of <i>Clostridium thermocellum</i> during anaerobic biomass-degradation identifies functional spirosomes.

bioRxiv : the preprint server for biology·2026
Same author

Structures of New World mammarenavirus glycoproteins as targets for antibody-mediated neutralization.

Journal of virology·2026
Same author

Instability Following Head and Liner Exchange: Eight-Fold Reduction in Dislocation With the Direct Anterior Approach.

The Journal of arthroplasty·2026
Same author

Variants in the proteasome regulator PSMF1 cause a phenotypic spectrum from parkinsonism to perinatal lethality.

Nature communications·2026
Same author

The Presence of Osteonecrosis in Patients Who Have Systemic Lupus Erythematosus Undergoing Total Knee Arthroplasty Is Not Associated With Worse Outcomes.

The Journal of arthroplasty·2026
Same author

Simultaneous Determination of Glucose and Cholesterol in Milk Samples by Means of a Screen-Printed Biosensor and Artificial Neural Networks.

Bioengineering (Basel, Switzerland)·2026
Same journal

Shaping the future of bioscience education: trends, challenges and community insights.

Emerging topics in life sciences·2026
Same journal

Perceived impact of field trips on students' sense of community, skills and knowledge in Biosciences and Chemistry undergraduate degrees.

Emerging topics in life sciences·2026
Same journal

Clinical assessment meets laboratory science: adapting OSCE methodology for authentic biosciences evaluation in the age of generative AI.

Emerging topics in life sciences·2026
Same journal

A holistic approach to addressing the degree awarding gap: a perspective.

Emerging topics in life sciences·2026
Same journal

Integrating Smart Worksheets into mandatory pre-laboratory exercises increased exercise completion rates and laboratory test grades.

Emerging topics in life sciences·2026
Same journal

Marking the markers: evaluating the potential of professional development through collaborative marking circles.

Emerging topics in life sciences·2026
See all related articles

Related Experiment Video

Updated: Nov 19, 2025

Author Spotlight: Advancing Protein Structure Analysis for Drug Development
07:08

Author Spotlight: Advancing Protein Structure Analysis for Drug Development

Published on: March 8, 2024

3.9K

Data-driven challenges and opportunities in crystallography.

Calina Glynn1, Jose A Rodriguez1

  • 1Department of Chemistry and Biochemistry, UCLA-DOE Institute for Genomics and Proteomics, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, U.S.A.

Emerging Topics in Life Sciences
|February 1, 2021
PubMed
Summary
This summary is machine-generated.

Structural biology is undergoing a revolution with advanced instruments generating vast data. New challenges in data processing and long-term storage require community-wide efforts for interpretation and accessibility.

Keywords:
cryoEMcrystallographydiffractionelectron microscopyserial crystallography

More Related Videos

The Automated Crystallography Pipelines at the EMBL HTX Facility in Grenoble
06:50

The Automated Crystallography Pipelines at the EMBL HTX Facility in Grenoble

Published on: June 5, 2021

3.9K
Derivatization of Protein Crystals with I3C using Random Microseed Matrix Screening
14:04

Derivatization of Protein Crystals with I3C using Random Microseed Matrix Screening

Published on: January 16, 2021

4.9K

Related Experiment Videos

Last Updated: Nov 19, 2025

Author Spotlight: Advancing Protein Structure Analysis for Drug Development
07:08

Author Spotlight: Advancing Protein Structure Analysis for Drug Development

Published on: March 8, 2024

3.9K
The Automated Crystallography Pipelines at the EMBL HTX Facility in Grenoble
06:50

The Automated Crystallography Pipelines at the EMBL HTX Facility in Grenoble

Published on: June 5, 2021

3.9K
Derivatization of Protein Crystals with I3C using Random Microseed Matrix Screening
14:04

Derivatization of Protein Crystals with I3C using Random Microseed Matrix Screening

Published on: January 16, 2021

4.9K

Area of Science:

  • Structural biology
  • Biophysics
  • Computational biology

Background:

  • Modern structural biology is experiencing rapid advancements driven by high-throughput instrumentation.
  • Increased data generation presents significant experimental and computational hurdles for real-time analysis and interpretation.
  • Existing data archival and retrieval methods are challenged by the scale of new datasets.

Purpose of the Study:

  • To address the challenges posed by the data deluge in structural biology.
  • To explore new research avenues, including macromolecular dynamics and molecular ensembles.
  • To foster community-wide collaboration for data management and analysis.

Main Methods:

  • Utilizing next-generation high-throughput instruments for structural data acquisition.
  • Developing advanced computational strategies for processing and interpreting large datasets.
  • Implementing robust data archival and retrieval systems for long-term accessibility.

Main Results:

  • Identification of new experimental and computational challenges associated with high-volume data.
  • Exploration of macromolecular dynamics and molecular ensembles for deeper biological insights.
  • Recognition of the need for enhanced data accessibility and community-driven data mining.

Conclusions:

  • The revolution in structural biology necessitates innovative solutions for data handling and interpretation.
  • Future research will focus on understanding conformational landscapes and molecular dynamics.
  • Collaborative efforts are crucial to maximize the scientific value of big data in structural biology.