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Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface
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The oral microbiome.

Liam P Shaw1,2,3, Andrew M Smith4, Adam P Roberts5

  • 1UCL Genetics Institute, UCL, London, U.K.

Emerging Topics in Life Sciences
|February 2, 2021
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Summary
This summary is machine-generated.

The human oral microbiome, though well-studied, remains complex. Research explores factors influencing its core and individual variations, impacting health and disease.

Keywords:
bacteria host interactionmicrobiomeoral cavity

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Area of Science:

  • Microbiology
  • Human Health
  • Oral Biology

Background:

  • The human microbiome's role in health and disease is increasingly recognized.
  • The oral microbiome is extensively studied due to accessible sampling.
  • Current understanding of oral microbial communities and host interactions is still developing.

Purpose of the Study:

  • To describe factors influencing the core oral microbiome's development.
  • To identify factors causing individual-level variations in the oral microbiome.
  • To explore oral microbiome-host interactions in health and disease.

Main Methods:

  • Literature review of factors affecting oral microbiome composition.
  • Analysis of studies on oral microbiome stability, resilience, and adaptability.
  • Exploration of research on oral microbiome's role in host health and disease.

Main Results:

  • Identified key factors shaping the conserved core oral microbiome.
  • Highlighted determinants of individual-specific oral microbiome profiles.
  • Discussed the oral microbiome's paradoxical stability and adaptability.

Conclusions:

  • The oral microbiome is shaped by both conserved and individual factors.
  • Understanding oral microbiome-host interactions is crucial for health and disease management.
  • Further research is needed to fully elucidate the complexities of the oral microbiome.