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Updated: Nov 18, 2025

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In Vivo Intravascular Pacing Using a Wireless Microscale Stimulator.

Parinaz Abiri1,2, Sandra Duarte-Vogel3, Tzu-Chieh Chou4

  • 1Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

Annals of Biomedical Engineering
|February 4, 2021
PubMed
Summary

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This summary is machine-generated.

This study presents a novel wireless cardiac pacing system designed to eliminate lead-related complications. The leadless pacemaker, deployed in the anterior cardiac vein, successfully powered cardiac pacing in animal models, demonstrating a safer alternative for arrhythmia treatment.

Area of Science:

  • Biomedical Engineering
  • Cardiology
  • Medical Devices

Background:

  • Permanent pacemakers are crucial for treating cardiac arrhythmias but carry risks, primarily from implantable leads.
  • Lead complications necessitate innovative solutions to improve patient safety and device longevity.

Purpose of the Study:

  • To develop and validate a leadless wireless cardiac pacing system.
  • To overcome the limitations of current wireless power transfer for deep-tissue implants.
  • To ensure the safety and efficacy of intravascularly deployed wireless pacemakers.

Main Methods:

  • Development of a transmitter-centered control system for efficient wireless power transfer.
  • Creation of a computational model for safety validation using MRI-based anatomical data.
Keywords:
Cardiovascular devicesImplantable pacemakerLeadless pacemakerWireless biomedical devicesWireless pacemakerWireless power transfer

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  • Fabrication of a pacemaker for intravascular deployment in the anterior cardiac vein (ACV).
  • Ex vivo and in vivo testing of the wireless pacing system in animal models.

    • Main Results:

    • The wireless system operated at over 50 times below tissue energy absorption safety limits.
    • Successful ex vivo cardiac pacing at 60 BPM and in vivo pacing at 120 BPM was achieved.
    • The pacemaker was successfully deployed in the ACV, demonstrating intravascular functionality.

    Conclusions:

    • Wireless intravascular pacing offers a promising leadless alternative to traditional pacemaker systems.
    • This technology has the potential to significantly reduce complications associated with lead-based cardiac implants.
    • The developed system demonstrates feasibility for safe and effective wireless cardiac pacing.