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Updated: Nov 18, 2025

Measuring Interactions of Globular and Filamentous Proteins by Nuclear Magnetic Resonance Spectroscopy NMR and Microscale Thermophoresis MST
Published on: November 2, 2018
Ultrafast diffusion-based unmixing of 1H NMR spectra
Rituraj Mishra1, Achille Marchand, Corentin Jacquemmoz
1Université de Nantes, CNRS, CEISAM UMR 6230, F-44000 Nantes, France. jean-nicolas.dumez@univ-nantes.fr.
Abstract:
We show that the NMR spectra of components in a mixture can be separated using 2D data acquired in less than one second, and an algorithm that is executed in just a few seconds. This NMR unmixing method is based on spatial encoding of the translational diffusion coefficients of the mixture's components, with multivariate processing of the data. This requires a new frequency swept pulse, which is designed and implemented to obtain quadratic spacing of the spatially parallelised gradient dimension. Ultrafast NMR unmixing may help in the analysis of mixtures that evolve in time.
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