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Multi-Solvent Suppression Ultrafast 2D COSY for High-Throughput Wine Screening.

Pia S Mayer1, Jérémy Marchand2, Marine P M Letertre2

  • 1Department of Food Science, University of Copenhagen, Frederiksberg, Denmark.

Magnetic Resonance in Chemistry : MRC
|January 18, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces an improved Nuclear Magnetic Resonance (NMR) method for rapid wine analysis. The new technique efficiently suppresses water and ethanol signals, enabling better identification of key wine metabolites within a practical timeframe.

Keywords:
1H2DCOSYNMRhigh‐throughput analysissolvent suppressionultrafastwine

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Area of Science:

  • Analytical Chemistry
  • Spectroscopy
  • Food Science

Background:

  • Nuclear Magnetic Resonance (NMR) is crucial for wine metabolite analysis.
  • 1D 1H NMR faces signal overlap issues in complex mixtures like wine.
  • Conventional 2D NMR methods are time-consuming and struggle with water/ethanol signal interference.

Purpose of the Study:

  • To develop a faster NMR method for wine analysis.
  • To suppress interfering water and ethanol signals in wine NMR spectra.
  • To enhance metabolite identification and discrimination in wine metabolomics.

Main Methods:

  • Adaptation of interleaved ultrafast COSY (iuf-COSY) experiment for wine analysis.
  • Utilized a shaped pulse and a NOESY block for efficient solvent signal suppression.
  • Acquired a 2D COSY spectrum of wine within approximately 20 minutes.

Main Results:

  • Successfully suppressed water and ethanol signals in wine NMR spectra.
  • Identified important metabolites previously masked by solvent signals.
  • Observed minimal interleaving artefacts in the resulting 2D COSY spectrum.

Conclusions:

  • The adapted iuf-COSY is an efficient method for rapid wine NMR analysis.
  • This technique aids in identifying and discriminating wine metabolites via additional cross peaks.
  • The method supports high-throughput wine metabolomics, quality control, and authenticity studies.