Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

122
Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
122
Dosage Regimen: Fixed Dose01:01

Dosage Regimen: Fixed Dose

2.2K
Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
2.2K
Drug Dosage Regimen: Overview01:15

Drug Dosage Regimen: Overview

4.1K
A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
4.1K
Dosage Regimen Designs: Nomograms and Tabulations01:23

Dosage Regimen Designs: Nomograms and Tabulations

75
Nomograms and tabulations are vital tools used by clinicians to design accurate and individualized dosage regimens. These instruments provide a straightforward method for adjusting dosages based on individual patient characteristics, including age, weight, and physiological condition. The foundation of a drug's nomogram is population pharmacokinetic data collected and analyzed using specific models. This data simplifies complex equations, presenting them diagrammatically or tabularly for easy...
75
Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

71
Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
71
Drug Accumulation During Multiple Dosing: Repetitive IV Injections01:21

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

117
Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...
117

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Standardization of measurement and reporting of medication adherence using the TEN-SPIDERS tool for claims data.

British journal of clinical pharmacology·2026
Same author

Microbiology testing around the time of antibiotic initiation among residents of long-term care facilities.

The Journal of antimicrobial chemotherapy·2026
Same author

Abrupt discontinuation and tapering of antipsychotics in older adults with dementia: a target trial emulation study.

The lancet. Healthy longevity·2026
Same author

A prospective, observational, cost of implementation analysis for the National Infection Surveillance Program for Aged Care (NISPAC).

Antimicrobial resistance and infection control·2026
Same author

Trends in microbiology testing in Australian long-term care facilities: national cohort study.

BMC infectious diseases·2026
Same author

Rapid Access Atrial Fibrillation Clinics in Australia - Modelling Outcomes and Cost-Effectiveness.

American journal of cardiovascular drugs : drugs, devices, and other interventions·2026
Same journal

The external clinical teaching visit: GP supervisor engagement and perceptions of utility.

Australian journal of general practice·2026
Same journal

Time to re-examine penicillin allergy in Australian general practice.

Australian journal of general practice·2026
Same journal

No place like home: The role of general practitioners in a housing crisis.

Australian journal of general practice·2026
Same journal

Expanding Medicare access for treating opioid dependence.

Australian journal of general practice·2026
Same journal

How to thrive in general practice training: A practical guide.

Australian journal of general practice·2026
Same journal

The VETERANS lens: A new tool to enhance consultations with veteran patients.

Australian journal of general practice·2026
See all related articles

Related Experiment Video

Updated: Nov 18, 2025

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
11:15

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

Published on: July 24, 2021

5.1K

Strategies to simplify complex medication regimens.

J Simon Bell1, Brigid McInerney2, Esa Yh Chen3

  • 1BPharm (Hons), PhD, MPS, Professor and Director, Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Vic.

Australian Journal of General Practice
|February 5, 2021
PubMed
Summary
This summary is machine-generated.

Simplifying medication regimens for older adults can reduce medication errors and hospitalizations. Strategies include consolidating doses, using long-acting medications, and deprescribing, prioritizing patient preferences and clinical judgment.

More Related Videos

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

30.8K
Diagonal Method to Measure Synergy Among Any Number of Drugs
12:08

Diagonal Method to Measure Synergy Among Any Number of Drugs

Published on: June 21, 2018

19.1K

Related Experiment Videos

Last Updated: Nov 18, 2025

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
11:15

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

Published on: July 24, 2021

5.1K
A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

30.8K
Diagonal Method to Measure Synergy Among Any Number of Drugs
12:08

Diagonal Method to Measure Synergy Among Any Number of Drugs

Published on: June 21, 2018

19.1K

Area of Science:

  • Gerontology
  • Pharmacology
  • Healthcare Management

Background:

  • Older adults often manage complex medication schedules.
  • Complexity poses challenges for administration, especially with cognitive or physical impairments.
  • Complex regimens are associated with medication non-adherence, errors, and hospital admissions.

Purpose of the Study:

  • To outline strategies for simplifying medication regimens in aged care settings.
  • To address the challenges of complex medication management in older populations.

Main Methods:

  • Medication regimen simplification involves reducing medication burden.
  • Strategies include consolidating dosing times and standardizing administration routes.
  • Utilizing long-acting formulations and combination products are key approaches.

Main Results:

  • Simplification aims to improve medication adherence and reduce errors.
  • Key preparatory steps include medication history, therapy appropriateness review, and deprescribing.
  • Implementation requires patient-centered discussions and clinical judgment to mitigate risks.

Conclusions:

  • Medication regimen simplification is crucial for safe and effective pharmacotherapy in older adults.
  • A multidisciplinary approach considering patient preferences is essential.
  • Simplification strategies can enhance quality of care and reduce adverse events in aged care settings.