A body shape index (ABSI) and endometrial pathology

Area of Science:

• Reproductive Medicine
• Oncology
• Public Health

Background:

• Obesity is a known risk factor for endometrial cancer (EC).
• Abdominal adiposity, evaluated by A Body Shape Index (ABSI), requires further investigation as a potential EC risk factor.
• Increasing EC incidence highlights the need for novel risk factor identification in women's health.

Purpose of the Study:

• To investigate the association between A Body Shape Index (ABSI) and endometrial pathology, including endometrial cancer (EC).

Main Methods:

• A cohort of 408 women was analyzed, categorizing them into four groups: no endometrial pathology, endometrial polyps, hyperplasia without atypia, and hyperplasia with atypia/cancer.
• A Body Shape Index (ABSI) and Body Mass Index (BMI) z-scores were calculated for all participants.
• Statistical analyses, including Kruskal-Wallis and multivariate analyses, were employed to determine correlations.

Main Results:

• A statistically significant correlation was observed between ABSI and the presence of endometrial cancer or atypical hyperplasia (p = .042).
• Multivariate analysis indicated that both ABSI and BMI z-scores might be associated with EC presence.
• Higher ABSI and BMI z-score quintiles showed a potential link to increased EC risk (p = .039 for ABSI, p = .038 for BMI).

Conclusions:

• This study found a significant association between A Body Shape Index (ABSI) and endometrial cancer/atypical hyperplasia.
• ABSI warrants further investigation as a potential independent risk factor for endometrial cancer.
• These findings may contribute to improved risk assessment and early detection strategies for endometrial pathology.