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Updated: Nov 18, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
From clinical decision support to clinical reasoning support systems.
Sophie van Baalen1, Mieke Boon2, Petra Verhoef1
1Rathenau Instituut, Den Haag, The Netherlands.
Artificial intelligence in healthcare, specifically clinical decision support systems (CDSS), should be viewed as clinical reasoning support systems (CRSS). This hybrid intelligence model combines AI
Area of Science:
- Medical Informatics
- Artificial Intelligence in Healthcare
- Epistemology of Medicine
Background:
- The adoption of artificial intelligence (AI) in healthcare is hindered by slow uptake.
- Clinical decision support systems (CDSS) present unique epistemological challenges.
- Understanding the epistemic tasks of medical professionals is crucial for AI integration.
Purpose of the Study:
- To analyze the epistemological issues in developing and implementing AI for clinical practice.
- To reframe CDSS as clinical reasoning support systems (CRSS).
- To define requirements for effective CRSS development and responsible use.
Main Methods:
- Conceptual analysis of medical professionals' epistemic tasks.
- Evaluation of CDSS capabilities in supporting clinical reasoning.
- Exploration of epistemological responsibilities in AI-assisted decision-making.
Main Results:
- CDSS should be conceptualized as CRSS to better support clinical reasoning.
- Effective CRSS require high-quality data and clinician interaction.
- Medical and AI experts must collaborate for successful CRSS development.
- Empirical justification of CRSS-generated data is essential for responsible use.
Conclusions:
- A hybrid intelligence model combining human and AI capabilities is proposed.
- CRSS excel at statistical reasoning and pattern detection.
- Clinicians remain essential for interpreting, integrating, and contextualizing AI-driven insights.
- Responsible CRSS implementation enhances, rather than replaces, clinical expertise.
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