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Quantification of Reactive Oxygen Species Using 2′,7′-Dichlorofluorescein Diacetate Probe and Flow-Cytometry in Müller Glial Cells
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Oxidative Stress and the Role of NADPH Oxidase in Glaucoma

Jennifer C Fan Gaskin1, Manisha H Shah1, Elsa C Chan1,2

  • 1Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne 3002, Australia.

Antioxidants (Basel, Switzerland)
|February 9, 2021
PubMed

Insights

Oxidative stress, driven by NADPH oxidase (NOX) enzymes, contributes to retinal ganglion cell death in glaucoma. Targeting NOX may offer new therapeutic strategies for this neurodegenerative eye disease.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Cell Biology

Background:

  • Glaucoma involves retinal ganglion cell loss and complex pathophysiological pathways.
  • Oxidative stress is a key mechanism in neurodegenerative diseases, including glaucoma.
  • NADPH oxidase (NOX) enzymes are significant producers of reactive oxygen species (ROS).

Purpose of the Study:

  • To review the role of oxidative stress in glaucoma pathogenesis.
  • To explore the influence of NOX expression on glaucoma.
  • To identify potential therapeutic targets for glaucoma treatment.

Main Methods:

  • Literature review of experimental glaucoma models.
  • Analysis of NOX expression and ROS production in retinal diseases.
  • Examination of oxidative stress mechanisms in retinal ganglion cell apoptosis.

Main Results:

  • Mounting evidence links NOX-derived ROS to oxidative stress in glaucoma.
  • NOX enzymes are implicated as a significant source of oxidative damage in the retina.
  • Experimental models illustrate the impact of NOX on glaucoma pathogenesis.

Conclusions:

  • Oxidative stress plays a complex role in glaucoma.
  • NOX enzymes are critical mediators of oxidative stress in glaucoma.
  • Targeting NOX pathways presents a promising therapeutic avenue for glaucoma.
Keywords:
NOXglaucomaneurodegenerationoxidative stressreactive oxygen speciesretinal ganglion cells

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