Efficient one-pot synthesis of substituted diphenyl 1, 3-thiazole through multicomponent reaction by using green and
Manjit Singh1, Vijay B Yadav2, Mohd Danish Ansari2
1Department of Chemistry IIT BHU, Varanasi, India.
Abstract:
A clean and efficient, multi-component strategy for the synthesis of biologically important trisubstituted thiazole via the reaction of readily available barbituric acid, acetophenone, and aryl thioamides is reported in the presence of FeCl3.6H2O / O2(Air) in DMF solvent. The advantages of the present methodology include a one-pot reaction, environment-friendly approach, cost-effectiveness, broad substrate scope, operational simplicity, short reaction time, easy workup procedure, and high yields.
Related Concept Videos
Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions
Alkenes via Reductive Coupling of Aldehydes or Ketones: McMurry Reaction
Preparation and Reactions of Thiols
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
β-Dicarbonyl Compounds via Crossed Claisen Condensations
Cycloaddition Reactions: Overview
![Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F51444.jpg&w=3840&q=50)

